阿司匹林对PIK3CA突变结肠癌开户送体验金有效_科研在线_抗癌健康网 - 开户送体验金
欢迎来到抗癌健康网!  
放入收藏夹 | 返回首页

开户送体验金

2018-09-13

抗癌健康网

手机看网页

导读:哈佛大学公共卫生学院流行病学部门首席研究员Shuji Ogino副教授说:阿司匹林可以增加结直肠癌开户送体验金的生存期。

2012年10月25日 讯 /生物谷BIOON/ --近日,一项新的研究发现晚期大肠癌开户送体验金,如果他们存在一特定的基因突变,阿司匹林可能延长他们的生命。

哈佛大学公共卫生学院流行病学部门首席研究员Shuji Ogino副教授说:阿司匹林可以增加结直肠癌开户送体验金的生存期,如果肿瘤有PIK3CA突变的话。但假如开户送体验金不存在PIK3CA突变,阿司匹林就不能正常发挥作用。根据这项研究证实:大约20%的大肠癌有PIK3CA突变。PIK3CA突变可作为遗传标记诊断预测大肠癌开户送体验金的突变情况。

 

基于一个简单的PIK3CA测试结果,医生可以给予或不给予开户送体验金阿司匹林。因此,PIK3CA测试有可能将大肠癌开户送体验金区分开来。但Ogino警告说:然而,研究结果还有待证实。在开展一个独立的验证研究之前,PIK3CA测试是否可以成为常规临床工作的测试方法还有待研究。这项最新研究发表在New England Journal of Medicine杂志上,Ogino团队收集到的数据涉及到900多名大肠癌开户送体验金。

这些数据包括他们服用阿司匹林情况以及他们是否有PIK3CA基因突变。研究人员发现,97%的PIK3CA基因突变的开户送体验金在服用阿司匹林后,自被确诊后五年中仍然存活, 而不服用阿司匹林的开户送体验金只有74%的存活率。然而,阿司匹林,对PIK3CA基因未突变的寿命没有明显影响。

Ogino说:在这项研究中,阿司匹林的最佳剂量是未知的。虽然一些新的药物在过去的十年中已经证实对转移性结直肠癌有疗效,其中只有奥沙利铂已被证明可阻止局部晚期癌症疾病开户送体验金肿瘤复发。因此,研究人员希望阿司匹林老药新用,开发其大肠癌治疗作用。(生物谷:Bioon.com)

doi:10.1056/NEJMoa1207756
PMC:
PMID:

Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival

Xiaoyun Liao, M.D., Ph.D., Paul Lochhead, M.B., Ch.B., Reiko Nishihara, Ph.D., Teppei Morikawa, M.D., Ph.D., Aya Kuchiba, Ph.D., Mai Yamauchi, Ph.D., Yu Imamura, M.D., Ph.D., Zhi Rong Qian, M.D., Ph.D., Yoshifumi Baba, M.D., Ph.D., Kaori Shima, D.D.S., Ph.D., Ruifang Sun, M.B., Katsuhiko Nosho, M.D., Ph.D., Jeffrey A. Meyerhardt, M.D., M.P.H., Edward Giovannucci, M.D., M.P.H., Sc.D., Charles S. Fuchs, M.D., M.P.H., Andrew T. Chan, M.D., M.P.H., and Shuji Ogino, M.D., Ph.D.

Background Regular use of aspirin after a diagnosis of colon cancer has been associated with a superior clinical outcome. Experimental evidence suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also known as cyclooxygenase-2) by aspirin down-regulates phosphatidylinositol 3-kinase (PI3K) signaling activity. We hypothesized that the effect of aspirin on survival and prognosis in patients with cancers characterized by mutated PIK3CA (the phosphatidylinositol-4,5-bisphosphonate 3-kinase, catalytic subunit alpha polypeptide gene) might differ from the effect among those with wild-type PIK3CA cancers.

Methods We obtained data on 964 patients with rectal or colon cancer from the Nurses' Health Study and the Health Professionals Follow-up Study, including data on aspirin use after diagnosis and the presence or absence of PIK3CA mutation. We used a Cox proportional-hazards model to compute the multivariate hazard ratio for death. We examined tumor markers, including PTGS2, phosphorylated AKT, KRAS, BRAF, microsatellite instability, CpG island methylator phenotype, and methylation of long interspersed nucleotide element 1.

Results Among patients with mutated-PIK3CA colorectal cancers, regular use of aspirin after diagnosis was associated with superior colorectal cancer–specific survival (multivariate hazard ratio for cancer-related death, 0.18; 95% confidence interval [CI], 0.06 to 0.61; P<0.001 by the log-rank test) and overall survival (multivariate hazard ratio for death from any cause, 0.54; 95% CI, 0.31 to 0.94; P=0.01 by the log-rank test). In contrast, among patients with wild-type PIK3CA, regular use of aspirin after diagnosis was not associated with colorectal cancer–specific survival (multivariate hazard ratio, 0.96; 95% CI, 0.69 to 1.32; P=0.76 by the log-rank test; P=0.009 for interaction between aspirin and PIK3CA variables) or overall survival (multivariate hazard ratio, 0.94; 95% CI, 0.75 to 1.17; P=0.96 by the log-rank test; P=0.07 for interaction).

Conclusions Regular use of aspirin after diagnosis was associated with longer survival among patients with mutated-PIK3CA colorectal cancer, but not among patients with wild-type PIK3CA cancer. The findings from this molecular pathological epidemiology study suggest that the PIK3CA mutation in colorectal cancer may serve as a predictive molecular biomarker for adjuvant aspirin therapy. (Funded by The National Institutes of Health and others.)

在这里,掌握健康资讯

扫描左侧二维码即可添加抗癌健康网官方微信;
健康之路 与你同行
肠癌更多>>
肠癌是胃肠道中常见的恶性肿瘤,发病率仅次于胃和食管癌,是大肠癌的最常见部分(占60%左右)。[详情]
热文欣赏更多>>

健康阅读

推荐欣赏

  • 热门推荐
  • 最新期刊
  • 疾病关注
长期憋尿,膀胱癌,长期憋尿引发膀胱癌
[详情]
白血病与骨髓移植术
[详情]
筷子致癌?靠什么吃饭?
[详情]
卵巢囊肿并不可怕
[详情]
调理内分泌多吃黄色2017开户送体验金
[详情]
吃腐乳致癌可信吗?
[详情]
资讯排行榜更多>>
肺癌康复指南吃什么?
信息聚焦更多>>
化疗药物中成药止痛药
卡铂珍香胶囊阿司匹林
顺铂参丹散结胶囊扑热息痛
5-氟尿嘧啶食道平散盐酸哌替啶片
西妥昔单抗抗癌平丸吗啡
多柔比星志苓胶囊芬太尼
视频推荐更多>>
肿瘤热文欣赏更多>>

特别声明:本站信息仅供参考 不能作为诊断及医疗的依据平台联系我们

抗癌健康网 版权所有 未经授权请勿转载  CopyRight©2008-2018 www.gaming-nexus.net, All Rights Reserved. 浙ICP备11014848号